microAmes Screen Test

A new microAmes screen fully predicts the GLP regulatory Ames test (Salmonella/E. coli Mammalian Microsome Reverse Mutation Assay). Evaluating compounds for mutagenic potential using the GLP regulatory Ames test is require for most small molecules prior to compound scale-up and IND-enabling non-clinical studies. Producing well-characterized test material of sufficient quantity to conduct a regulatory Ames test takes considerable investment both in the chemical synthesis and in running a full plate GLP Ames test, activities which can take months to complete. Using approximately 5-10 mg of chemist bench sample, MBR can screen for Ames mutagenicity in two weeks or less. By relying on experienced experts, MBR generates an accurate answer on Ames mutagenicity during lead optimization.

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